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KMID : 0980320220220020097
Journal of Dental Anesthesia and Pain Medicine
2022 Volume.22 No. 2 p.97 ~ p.105
The anti-nociceptive effect of BPC-157 on the incisional pain model in rats
Jung Young-Hoon

Kim Hae-Kyu
Kim Hyae-Jin
Kim Eun-Soo
Baik Ji-Seok
Kang Hyun-Jong
Abstract
Background: The pentadecapeptide BPC-157 has been shown to have anti-inflammatory and wound healing effects on multiple target tissues and organs. Peptides have potent anti-inflammatory effects on periodontal tissues in rats with periodontitis. Few studies have investigated the effect of BPC-157 on pain after dental procedures or oral surgeries. The purpose of the present study was to investigate the antinociceptive effects of BPC-157 on postoperative incisional pain in rats.

Methods: Sprague?Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 ¥ìg/kg of BPC-157), BPC20 (20 ¥ìg/kg of BPC-157), BPC40 (40 ¥ìg/kg of BPC-157), and morphine (5 mg/kg of morphine). A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats. Withdrawal responses were measured using von Frey filaments at 0, 2, 6 h and 4, 7 d after incision. The formalin test was also performed to differentiate its anti-nociceptive effect from an inflammatory reaction or central sensitization. Pain behavior was quantified periodically in phases 1 and 2 by counting the number of flinches in the ipsilateral paw after injection with 30 ¥ìL of 5% formalin.

Results: The threshold of mechanical allodynia was significantly increased in the BPC10, BPC20, BPC40 and morphine groups compared with that in the control group at 2 h. These increasing thresholds then returned to the levels of the control group. The BPC-157 group showed a much higher threshold at 4 days after incision than the control group. The thresholds of the BPC groups, except the morphine group, were normalized 7 days after incision. The flinching numbers of the BPC10, BPC20, BPC40 and morphine groups were significantly decreased in phase 1, but there was no decrease in the BPC-157 groups except the morphine group in phase 2.

Conclusions: BPC-157 was effective only for a short period after incision. It was also effective during phase 1 but not during phase 2, as determined by the formalin test. BPC-157 might have a short antinociceptive effect, even though it has anti-inflammatory and wound healing effects.
KEYWORD
BPC-157, Formalin Test, Incisional Pain Model, Mechanical Allodynia
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